Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. it is administered by the intravenous, epidural and sublingual route
Indication:
- Analgesic adjunct.
- Maintenance of general anesthesia.
Mechanism of Action:
Opioid agonist, Selective μ, mu or MOP receptor agonist.
Potency:
10-15 times than fentanyl.
Clearance:
Hepatic metabolism ( N-dealkylation and O-demethylation.)
Dose & Route:
Continuous Infusion: 0.3 -1 mcg/kg/hr
Bolus: 0.1 – 0.5 mcg/kg IV.
Side Effect:
- Respiratory depression.
- Hypotension and bradycardia in higher doses.
Synonyms:
Sufentanil, Sufentanilo, Sufentanilum, Sufentanyl