Sufentanil

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    Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. it is administered by the intravenous, epidural and sublingual route

    Indication:

    • Analgesic adjunct.
    • Maintenance of general anesthesia.

    Mechanism of Action:

    Opioid agonist, Selective μ, mu or MOP receptor agonist.

    Potency:

    10-15 times than fentanyl.

    Clearance:

    Hepatic metabolism ( N-dealkylation and O-demethylation.)

    Dose & Route:

    Continuous Infusion: 0.3 -1 mcg/kg/hr

    Bolus: 0.1 – 0.5 mcg/kg IV.

    Side Effect:

    • Respiratory depression.
    • Hypotension and bradycardia in higher doses.

    Synonyms:
    Sufentanil, Sufentanilo, Sufentanilum, Sufentanyl
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