Remifentanil

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    Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone and causes respiratory depression and analgesia.(Drug Bank)

    Indication:

    • MAC
    • Maintenance of general anesthesia.

    Mechanism of Action:

    Opioid agonist, Selective μ, mu or MOP receptor agonist.

    Potency:

    Ultra-short-acting

    Clearance:

    40 ml/min/kg

    Route of elimination

    Esterase-metabolized opioid, also excreted by the kidneys

    Metabolism/Metabolites

    Hydrolysis.

    Dose & Route:

    MAC Anesthesia: 0.02-0.05mcg/kg/IV

    Continuous Infusion: 0.3-1.0 mcg/kg/hr/IV

    Biological Half-Life

    10-20 minutes.

    Side Effect:

    • Respiratory depression.
    • Nausea, Vomiting
    • Skeletal muscle rigudity
    • Purposeless movements
    Synonyms:
    Remifentanl, Remifentanilo, Ultiva
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