Alfentanil is a short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and a fast recovery of consciousness. Alfentanil is effective as an anesthetic during the surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. Drug Bank.
Indication:
- Postoperative pain management
- Maintenance of general anesthesia.
Mechanism of Action:
Opioid agonist, Selective μ, mu or MOP receptor agonist.
Potency:
10 times than morphine. Smaller volume of distribution than fentanyl
Clearance:
Hepatic metabolism ( N-dealkylation and O-demethylation.)
Metabolism/Metabolites
Liver is the major site of bio-transformation.
Dose & Route:
Rapid onset bolus: 120mcg/kg IV.
Continuous Infusion: 25-100mch/kg/hr/IV
Biological Half-Life
90-111 minutes
Side Effect:
- Respiratory depression.
Synonyms:
1-[2-(4-aminophenyl)ethyl]-4-phenyl-4-piperidinecarboxlic acid ethyl ester, Anileridina, Anileridine, Anileridinum